Author Edward Flynn’s Blog

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Author Brief Biography

Degree

PhD                                                    Physics                                   University of New Mexico

Positions

Staff Member                                    Los Alamos National Lab    Los Alamos, NM

Nuclear Physics Group leader     Los Alamos National Lab    Los Alamos, NM

Biophysics Group Leader               Los Alamos National Lab    Los Alamos, NM

Fellow                                                  Los Alamos National Lab    Los Alamos, NM

Adjunct Professor                             Physics Dept.                           University of New Mexico

Research Professor                           Computer Engineering       University of New Mexico

Member                                              UNM Cancer Center             University of New Mexico

Honors and Assignments at Various Institutions

NSF-NATO Fellow                            Niels Bohr Institute                  Copenhagen, Denmark

Visiting Professor                             Physics Dept.                             University of Colorado

Von Humboldt Prize winner         Hahn-Meitner Institute         Berlin, Germany

Wellcome Trust Award                   Strathclyde University            Glasgow, Scotland

Fellow                                                  American Physical Society

Fellow                                                  Los Alamos National Laboratory

Companies and Foundations

Founder and Chief Scientist            Senior Scientific, LLC              Albuquerque, NM

Founder and First president            Mind Research Network       Albuquerque, NM

Patents

Superconducting Imaging Gradiometry                                              5,008,622

Magnetic Needle Biopsy                                                                      7,309,316 and 8,118,754

Biomagnetic detection and treatment of Alzheimer’s Disease            8,060,179

Magnetic Needle Separation and Optical Monitoring                         9,964,469

Contributions to Science

 Nuclear Physics:  Dr. Flynn’s career as a nuclear physicist spanned some 25 years and specialized in experimental measurements of fundamental modes of nuclear states. This included: a) measurements of single particle states of through nuclear reaction studies using tritium beams from accelerators, b) pairing vibrational states through two-neutron stripping reactions, c) measurements of Gamov-Teller states through charge exchange reactions and heavy ion experiments using carbon-14 beams. Data from pairing vibrational studies were used by A. Bohr and B. Mottelson in their Nobel prize winning nuclear theory and in their book on nuclear theory. Data on Gamov-Teller states were used by W. Fowler in his Nobel prize studies involving the inverse-r process of element buildup.

Four of 170 publications in nuclear physics:

R. A. Broglia, S. Landowne, V. Paar, B. Nilsson, D. R. Bès, E. E. Flynn, Coupling between inelastic and pair transfer degrees of freedom. The 208Pb(t, p) 210Pb(3) reaction analyzed in the coupled channel born approximation, Physics Letters BVolume 36, Issue 618 October 1971, Pages 541-546
E. R. Flynn and R. H. Bassel Importance of the Imaginary Term in Distorted-Wave Born-Approximation Calculations of 3He Inelastic Scattering, Phys. Rev. Lett. 15, 168 (1965)
72) E. R. Flynn and J. D. Garrett, Excitation of the Parent Analogs of the 58Ni Giant M1 Resonance by the Reaction 58Ni(t,h)58Co, Phys. Rev. Lett. 29, 1748 (1972)
W. von Oertzen, E. R. Flynn, J. D. Garrett, and E. Cosman, Supermultiplet Symmetry in the Reaction 3H + 9Be → 6Li + 6He, 6Li* + 6He, Phys. Rev. Lett. 32, 34 (1974)
F. Ajzenberg-Selove, Ronald E. Brown, E. R. Flynn, and J. W. Sunier, (t,3He) reactions on 40,42,44Ca, 46,48,50Ti, 54Cr, and 54Fe, Phys. Rev. C 32, 756 (1985)

Example of nuclear physics results used in the studies of Nobel prize winners Ben Mottelson and Aage Bohr in their book Nuclear Structure Volume 2

nuclear physics

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Magnetoencephalography (MEG):  Dr. Flynn was the founder of the biophysics group at Los Alamos National Laboratory with an emphasis on MEG, inverse EM theory, and graphics to carry out basic research in brain imaging and function. Programs in visual, auditory and somatosensory stimuli were performed to provide detailed mapping of function in adult human brains using SQUID sensor arrays. Substantial effort was directed towards the physics of the EM phenomenon associated with MEG and solving for localization of sources in the brain and design of a new technique for SQUID gradiometry. This program was funded by NIBIB and resulted in a patent on magnetic imaging gradiometry.

Four of 65 publications in MEG:

Volegov, R.H. Kraus, Jr., K. Maharajh, A. Matlachov, M. Espy, and E.R. Flynn, Imaging Magnetic Sources in the Presence of Superconducting Surfaces: Model & Experiment, Biomed. Technik, 46:159 (2001)
Akhtari, H. Bryant, A. Mamalek, E. Flynn, L. Heller, J. Shih, M. Mandelkern , A. Matlachov, D. Ranken E. Best, W. Sutherling, Conductivities of Three-Layer Human Skull, Brain Topography 13:1-14 (2000)
van Hulsteyn, A. Petschek, E. Flynn, W. Overton, Superconducting imaging surface magnetometry, Rev. Sci. Instr. 66, 3777-3784. 1995
Arthur, P. Lewis, P. Medvick, E. Flynn, A Neuromagnetic Study of Selective Auditory Attention, EEG 78, p348-360, 1991

Example of SQUID designs and neuromagnetic data from MEG program

MEG

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Cancer Research. Dr. Flynn’s goal of the superparamagnetic relaxometry (SPMR) program was to use ultrasensitive magnetic SQUID and atomic magnetometer sensors in magnetic relaxometry measurements to provide detection and localization of cells in the body that are responsible for disease. Magnetic nanoparticles (NP) labeled with Ab were used to target cells. Dr. Flynn used his expertise to design magnetic sensors for biophysical applications utilizing the special properties of superparamagnetic nanoparticles. Applications include early detection of transplant rejection and of cancer and other diseases utilizing magnetic markers delivered in-vivo or in-vitro in animals and eventually humans. A magnetic biopsy needle was designed that significantly increases the sensitivity for detection of cancer cells in the marrow and blood. Dr. Flynn has been actively involved in the development of new nanoparticles and coatings with good monodispersity and magnetic strength properties as well as new methods for solving the inverse problem in EM to localize cancer sources from magnetic field measurements.

Four of 16 publications in Cancer Research:

Flynn ER., Bryant, HC., A SQUID based system for in-vivo cancer imaging, PMB 50 (2005) 1273-1293
Jaetao JE, Butler KS, Adolphi NL, Lovato, DM, Bryant HC, Rabinowitz I, Winter SS, Tessier TE, Hathaway HJ, Bergemann C, Flynn ER, and Larson RS, Enhanced Leukemia Cell Detection Using a Novel Magnetic Needle and Nanoparticles, Cancer Res 69 (21)2009, 8310-8316
Hathaway HJ, Butler KS, Adolphi NA, Lovato DM, Belfon R, Fegan DL, Monson TC, Trujillo JE, Tessier TE, Bryant HC, Huber DL, Larson RS, Flynn ER, A novel method for early detection of breast cancer using magnetic nanoparticles and ultra-sensitive magnetic field sensors, Breast Cancer Research 13:R108 (2011) PMID 22035507
Adolphi NA, Butler KS, Lovato DM, Tessier TE, Trujillo JE, Hathaway HJ, Fegan DM, Monson TC, Stevens TE, Huber DL, Ramu J, Milne ML, Conradi MS, Altobelli SA, Larson RS, Flynn ER, Imaging of Her2-targeted magnetic nanoparticles for breast cancer detection, Contrast Media and Molecular Imaging (2012) 7 308-319, PMID 22539401

Example of results of breast cancer studies using SPMR methods.

Cancer

Magnetoencephalography (MEG):  Dr. Flynn was the founder of the biophysics group at Los Alamos National Laboratory with an emphasis on MEG, inverse EM theory, and graphics to carry out basic research in brain imaging and function. Programs in visual, auditory and somatosensory stimuli were performed to provide detailed mapping of function in adult human brains using SQUID sensor arrays. Substantial effort was directed towards the physics of the EM phenomenon associated with MEG and solving for localization of sources in the brain and design of a new technique for SQUID gradiometry. This program was funded by NIBIB and resulted in a patent on magnetic imaging gradiometry.

Four of 65 publications in MEG:

Volegov, R.H. Kraus, Jr., K. Maharajh, A. Matlachov, M. Espy, and E.R. Flynn, Imaging Magnetic Sources in the Presence of Superconducting Surfaces: Model & Experiment, Biomed. Technik, 46:159 (2001)
Akhtari, H. Bryant, A. Mamalek, E. Flynn, L. Heller, J. Shih, M. Mandelkern , A. Matlachov, D. Ranken E. Best, W. Sutherling, Conductivities of Three-Layer Human Skull, Brain Topography 13:1-14 (2000)
van Hulsteyn, A. Petschek, E. Flynn, W. Overton, Superconducting imaging surface magnetometry, Rev. Sci. Instr. 66, 3777-3784. 1995
Arthur, P. Lewis, P. Medvick, E. Flynn, A Neuromagnetic Study of Selective Auditory Attention, EEG 78, p348-360, 1991

Example of SQUID designs and neuromagnetic data from MEG program

MEG